Aintzane Zabaleta, Mary Sartor, Ramón Lecumberri Villamediana, Rosanne Dunn, David Gottlieb, Jesús San Miguel; EHA Library. Zabaleta A. 06/13/2024; 421463; PB2697
Keywords: KappaMab | LambdaMab | AL Amyloidosis | KMA | LMA
Spencer, A., Kalff, A., Shortt, J., et al. A sequential cohort study evaluating single-agent KappaMab and KappaMab combined with lenalidomide and low-dose dexamethasone in relapsed and/or refractory kappa light chain-restricted multiple myeloma (AMaRC 01-16). Br J Haematol. 2023; Aug; 202(4):801-811.
https://doi.org/10.1111/bjh.18955.
Keywords: KappaMab | Phase 2b Clinical Trial | Kappa-type multiple myeloma | Lenalidomide | Dexamethasone
Spencer, A., Walker, P., Asvadi, P. et al. A preliminary study of the anti-κ myeloma antigen monoclonal antibody KappaMab (MDX-1097) in pretreated patients with κ-restricted multiple myeloma. Blood Cancer J. 2019; 9: 58.
https://doi.org/10.1038/s41408-019-0217-5
Keywords: KappaMab | Clinical Trial | Kappa-type multiple myeloma
Asvadi, P., Cuddihy, A., Dunn, R.D., et al. MDX‐1097 induces antibody‐dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide. Br J Haematol. 2015; 169: 333-343.
https://doi.org/10.1111/bjh.13298
Keywords: KappaMab | In vitro | ADCC | Free light chains | Lenalidomide
Wong, M., Asvadi, P., Dunn, R., et al. MDX-1097 Binds specifically to kappa myeloma cells and anti-tumour activity is mediated by multiple effector cells. Blood. 2009; 114(22): 1846.
Dunn, R.D., Weston, K.M., Longhurst, T.J., et al. Antigen binding and cytotoxic properties of a recombinant immunotoxin incorporating the lytic peptide, melittin. Immunotechnology. 1996; 2: 229-40.
Keywords: K-1-21 or mKap
Walker, K.Z., Boux, H.A., Hayden, G.E., et al. (1985). A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has a potential as a therapeutic agent. In: Microenvironments in the Lymphoid System. Editor: G.G.B Klaus, Plenum Publishing Corporation.
Keywords: Free light chains | K-1-21 or mKap
Raison, R.L. and Boux, H.A. Conformation dependence of a monoclonal antibody defined epitope on free human kappa chains. Mol Immunol. 1985; 22(12): 1393-98.
Keywords: K-1-21 or mKap | Epitope
Goodnow, C.C. and Raison, R.L. Structural analysis of the myeloma-associated membrane antigen KMA. J Immunol. 1985; 135(2): 1276-1280.
Keywords: KappaMab | K-1-21 or mKap
Boux, H.A., Raison, R.L., Walker, K.Z., et al. The surface expression of a tumor-associated antigen on human kappa myeloma cells. Eur. J Immunol. 1984; 14: 216-222.
Keywords: In vitro | Free light chains | K-1-21 or mKap | Epitope
Boux, H.A., Raison, R.L., Walker, K.Z., et al. A tumour-associated antigen specific for human kappa myeloma cells. J Exp Med. 1983; 158(5): 1769-74.
Keywords: In vitro | Free light chains | K-1-21 or mKap | Epitope